Psoriasis is rightfully termed as the Healthy Man’s Disease. Though characterised with intense scaling and itching, it does not directly have any further complications on the general health of the patient. Psoriasis generally has a chronic history with indolent lesions which persist for months and seldom has acute onset except Gutate Psoriasis and Generalised Pustular Psoriasis. A diagnosis of Psoriasis was made on the basis of signs and symptoms & correlated with Ekakushtha described in Ayurved texts. Ayurvedic management specially comprising of Panchkarma procedures and internal medications show significant improvement in all the cardinal symptoms as well as lesions of the patients. Treatment was carried out as Shodhan in the form of Virechan and Shaman in the form of internal medicines. The results found are very encouraging in this disease whose recurrence is also very high.