Meningiomas are predominantly benign tumors, which arise from the arachnoids’ cap cells . The development mechanism is unknown but they may result from an adverse effect of cranial irradiation and trauma. Recently Arbab etal reported in a study done at the National Center of Neurological Sciences, Khartom Sudan, the incidence of meningioma was found to be more than 65% of all intra cranial neoplasms. Material and methods: This is a cross-sectional hospital base study that had been performed at the National Center for Neurological Sciences during March 2015 to October 2015. Tumor specimens were obtained from 21 intracranial meningiomas’ treated at the National Center for Neurological Sciences. All tumors were classified according to the WHO guidelines (2007). Results: In this study strong expression of cd44 was observed in 75% of the fibrous G 1 meningioma, and 100% of the atypical G 11.
