Colorectal cancer (CRC) is the third most common type of cancer in the world. It’s rare in younger adults, known as aggressive cancer. The aim of our study is to describe the epidemiological, clinical and therapeutic profile to young people compared of elderly adults. Its comparative study of CRC in younger adults less than 40 years (G1) and elderly more than 40 years(G2) between 2014 and 2015, included all cases of CRC treated on Mohamed IV center for treatment of cancer. 330 patients were enrolled. (49 cases of G1 (14.1%) and 281 cases of G2 (85.1%).The sex ratio of 1.04 is noted. The first-degree history of CRC was reported in 11 cases in G1 (22.45 %) versus 25 in G2 (8.89 %) (p= 0.03).The primary location of CRC was rectum in G1 in 40.8 % of cases vs 51.6 % in G2. However, the sigmoid was the most common site of CRC in 2 groups. Mucinous adenocarcinomas were found more in the group G1 (24.49% in G1vs 13.16 % inG2) (p=0.01). Younger colorectal cancer (YCRC) is not a rare cancer in our country. Despite similar treatment patterns and survival outcomes, YCRC is more aggressive with poor prognosis.
