Klebsiella species including Klebsiella pneumoniae and Klebsiella oxitoca are one of the most common pathogen bacteria that cause a variety of infections. This study was conducted to find out the prevalence and antibacterial susceptibility patterns of Klebsiella species isolates at tertiary care university hospital in the central region of Japan from 2008 to 2010. Klebsiella species was identified by standard laboratory procedure. Antibacterial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Of seven hundred ten Klebsiella species, five hundred fiftyKlebsiellapneumoniae, and one hundred sixty Klebsiellaoxitoca were isolated. About four hundred seventy Klebsiella species isolates were from inpatient. The major source of Klebsiella isolates were sputum, and urine. Positive samples were received mostly from the urology, paediatrics, respiratory medicine, intensive care unit and surgery. The effective antibiotics with over 99% susceptibility rates were amikacin, imipenem, and meropenem. The numbers of extended-spectrum beta-lactamase (ESBL) producing isolates were thirty-five and eighteen Klebsiella species isolates had multidrug resistant ability. Klebsiella species infection spreads among community easily and inappropriate use of antibiotics contributes to their resistance. Continuous antibacterial susceptible surveys are indispensable to reduce the emergency of ESBL and multidrug resistance.
