Silver nanoparticles has great demand in biomedical sectors like antimicrobial agents, wound healing dressings, implants, coatings for contact lens, medical catheters. Their therapeutic efficacy has been improved for wound healing and burning cases by incorporating with hydrogel scaffold. Hydrogels are biocompatible aqueous polymer with capability to retain large quantity biological fluid within its cross linked 3-dimensional structure. Nanotechnology has improved the efficacy of these hydrogel products by nanohydrogel formulation using synthetic chemical agents and natural polymeric materials. Polymeric nanohydrogels exhibit high degree of biocompatibility, biodegradability, mechanical strength, molecular binding abilities in compare to synthetic chemical nanogels. This review article will highlight the synthesis of nanohydrogels, physiochemical characteristics, recent trends and major issues for development of different types of nanohydrogel for biomedical applications. An author has also discussed their significant limitations in terms of clinical potential, toxicity aspects, stability, and societal ethical issue.
