Background: Intact bacteria or bacterial products, including lipopolysaccharide (LPS), in the periodontal tissue may enter the bloodstream through inflamed periodontal tissue or via saliva. High-density lipoprotein (HDL) is considered as an antiatherogenic lipoprotein because of its direct role in neutralizing LPS in circulation and protecting low density lipoprotein (LDL) against oxidation as well as its role in reverse cholesterol transport. Apolipoproteins are proteins that bind to lipids to form lipoproteins; its main function is transporting lipids. Aim: The aim of the present study is to compare and evaluated serum titers of Apolipoprotein A1 in both chronic gingivitis and chronic periodontitis patients before and after scaling and root planing. Materials and Methods: The study included a total of 40 patients in which 20 are patients with chronic gingivitis and 20 are patients with chronic periodontitis. 5ml of non fasting blood was collected from the patients at baseline (before scaling and root planning), and after 3 months and sent to lab for evaluation of Apolipoprotein A1 (APO A1). Results: The Plaque index, gingival indices, Probing depth and Clinical attachment level are measured. The mean value of Apolipoprotein A1 in group A and group B is increased from baseline to 3 months of follow up. The p value is statically significant. Conclusion: The results showed that the mean value of Apolipoprotene A1 in group A and group B is increased from baseline to 3 months before and after scaling and root planing
