In the current study, flies from control and creatine monohydrate-treated medium were utilized to investigate the effect of creatine monohydrate in starvation resistance of Drosophila melanogaster. It was discovered that flies fed with control diet had significantly higher starvation resistance compared to flies maintained on creatine monohydrate treated media and starvation resistance decreased with increase creatine monohydrate concentration. It was also observed that female Drosophila melanogaster had significantly higher starvation resistance compared to both their mated and unmated male counterparts. It was further discovered that mated female were more resistant to starvation than unmated female flies whilst mated male flies were less resistant to starvation compared to unmated male flies. With observation made from the study, it was concluded that creatine monohydrate supplementation reduce starvation resistance in Drosophila melanogaster suggesting its negative effects on starvation resistance
