The present study was conducted to evaluate the effect of pre-anaesthetic combinations on clinico-physiological parameters such as glycopyrrolate-xylazine-butorphanol, glycopyrrolate-dexmedetomidine-butorphanol and glycopyrrolate-acepromazine-butorphanol on propofol induction and isoflurane maintenance general anaesthesia in 18 dogs of either sex presented to the Department of Veterinary Surgery & Radiology, College of Veterinary Science & Animal Husbandry, Kamdhenu University, Junagadh for varieties of surgeries. The heart rate showed non-significant reduction in xylazine group, non-significant higher in acepromazine group following pre-medication. During the maintenance period, heart rates remained within clinically normal range which could be due to less isoflurane required. The respiratory rate showed non-significant reduction following pre-medication and increased non-significantly during induction and maintenance in all the three groups. The rectal temperature showed non-significant decrease throughout the period when compared to the base values attributed to the hypothermic effects of general anaesthesia. The recovery was smooth, fast and uneventful without any complication during observation periods in all the groups. Among all the three groups, significant difference at various observation periods in any parameters was not observed. Hence, it is concluded that the glycopyrrolatedexmedetomidine-butorphanol with propofol induction and isoflurane maintenance was better followed by glycopyrrolate-acepromazine-butorphanol and glycopyrrolate-xylazinebutorphanol anaesthetic protocol for different orthopedic and soft tissue surgeries in dogs.
