Introduction: Work-related musculoskeletal disorders (WMSDs) are responsible for morbidity in many professions. Dentists as the health-care professionals are prone to develop WMSDs. Objectives: To analyse the prevalence of WMSDs and access factors affecting them among dental practitioners of Uttar Pradesh. Material and methods: A self-administered questionnaire, formulated using Google online survey tool was send to dentists, through E-mail, and social networking. Results:1) Overall prevalence of WMSDs for last 12 months was 75.5%. 2) 43.1% of practitioners reported WMSDs in lower back region followed by shoulder. 3) Majority of the practitioners who reported WMSDs were found to be overweight/obese.4) Higher prevalence of WMSDs was reported from practicing endodontic/restorative procedures followed by orthodontic procedures. 5)19.7% of study population is on the verge of abandoning the profession. Conclusion: Risk factors are highly predictive of developing WMSDs. Incorporation of Ergonomics and acquisition of such knowledge can minimize future contaminations in dental practice.