The aim of the study was assess the antibacterial effect of some weed plant extracts and their synergistic antibiotic against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa .Bacillus subtillis, Salmonella typhi. The extracts of medicinal plants were prepared using Soxhlet apparatus for alcoholic, methanolic, ethyl acetate, chloroformic extract and water reflux for aqueous extracts. The antibacterial activities of extracts were evaluated using the well diffusion method as; the inhibitory zones were recorded in millimeters. The minimal inhibitory concentration (MIC) of the plant extracts against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, Bacillus subtillis, Salmonella typhi. Were assessed using microdilution method. The synergistic effect between plants and extraction of antibiotics was assessed using well diffusion method. The results of this study showed that methanolic and ethyl actate extracts used against S. typhi was showed antimicrobial and synergistic effect for most antibiotics better.
