Introduction- Gestational diabetes mellitus is a common complication in pregnancy, affecting more than 10% pregnancies worldwide. However, the true underlying causes remain to be fully elucidated. Aims & Objective-The study aims at testing the hypothesis that elevated uric acid in first trimester of pregnancy associated with subsequent development of gestational diabetes. Material & Methods-This prospective observational study was conducted in the Department of Obstetrics and Gynaecology in Rama Medical College Hospital & Research Centre, KANPUR from November 2022 to October 2023. Total 50 pregnant women less than 12 weeks were included in this study after informed consent. Blood samples were collected for serum uric acid analysis and all these patients were followed up with oral glucose tolerance test 24-28 weeks of gestation. Result-Mean age of pregnant women was 27.7±5.1 years. The mean height and weight was 160±2.9cms and 58.9±3.2kg respectively. The body mass index of patients was 22.9±1.4 kg/m2. The mean gestational age of the pregnant women was 10.34±1.4 weeks. The mean uric acid was 3.2±1.4mg/dl. In this study the p value was 0.026 using chi-square test which was significant. Conclusion-There was increasedrisk of development of GDM with increased levels of serum uric acid in the first trimester.
