Oral mucosa is very much vulnerable to a large number of diseases. In the past decades, the adjunctive techniques have emerged with claims of enhancing oral mucosal examinations and facilitating the detection of premalignant and malignant lesions. The advancements in these fields have led to the development of diagnostic tools at both the clinical and molecular level for the early detection of oral mucosal lesions in the oral cavity which remains the best way to ensure patient survival and quality of life. As the era advances, now there is more impact on the genes and the molecules for the diagnosis of oral diseases. So, our emphasis is more concentrated on advanced techniques. Some of the recent adjunctive techniques which shows promising results for the detection of oral lesions are Vizilite, Autofluoroscence, VELscope, Oral CDx brush biopsy etc. This article highlights the importance of conventional as well as recent advanced techniques used in the diagnosis of oral lesions.
