Objectives: The objective of this study was to study the association of central obesitywith metabolic syndrome (MetS) and insulin resistance among medicalstudents. Materials and Methods: From December 2013 to July 2014, 125subjects (63 males and 62 females) between 18 to 22 years were recruited for the cross-sectional study. Anthropometric and biochemical data were collected. Central obesity was identified using Waist to Height Ratio (WHtR), MetS was identified by modified NCEP ATP III criteria for Asian Indian population and Insulin resistance was identified using Triglyceride to HDL Cholesterol Ratio (TG/HDL). Results: Metabolic syndrome was identified in 4% of the individuals who participated in the study. 80% of the subjects with MetS had insulin resistance and 80% of the subjects with MetS had central obesity. Conclusions: The individuals with risk for developing chronic lifestyle diseases is alarmingly high. Because of high rates of overweight/obesity and MetS, college-age adults are at risk for developing chronic diseases including diabetes mellitus and cardiovascular disease.