Del Nido cardioplegia is a favored choice in pediatric cardiac surgery, known for its unique composition with lidocaine to counteract potassium-induced depolarization, minimizing interruptions and enhancing surgical efficiency. Recent research extends its application to adult cardiac surgery, affirming its safety, efficacy, and cost-effectiveness. Limited availability of the standard base solution, Plasmalyte-A, in some regions hinders its use. An alternative approach with lactated Ringer's solution has been explored. This review investigates Modified Del Nido cardioplegia, focusing on myocardial protection and early clinical outcomes. In cardiac surgeries, myocardial protection is critical, as inadequate protection can lead to adverse outcomes. Traditional approaches minimize ischemic damage when the aorta is clamped. Del Nido cardioplegia, with its unique composition, demonstrates effectiveness in pediatric and adult cases, including enhanced cardiac index, shorter hospital stays, and reduced troponin release. Modified Del Nido, using lactated Ringer's, offers promise where Plasmalyte-A is unavailable, maintaining cardiac index and myocardial protection. In conclusion, Del Nido and Modified Del Nido cardioplegia represent significant advances in myocardial protection during cardiac surgery. Their effectiveness and cost-efficiency make them appealing options for various cardiac procedures, with the potential for further improvements in patient outcomes. In this review study we aim to investigate the outcomes of this modified Del Nido cardioplegia, assessing its impact on myocardial protection and early clinical results.
