Rapid Prototyping (RP) is an novel technology and emerging rapidly in medical & engineering applications. RP technology works on the principle of layer by layer manufacturing. Recent studies proves that Bio-RP plays a key role in tissue engineering, preplanning of complex medical surgeries, manufacturing of prosthesis, forensic pathology, surgical simulation, diagnosis, design & manufacturing of implants and as well as medical tools. This Bio-RP gives a new dimension to the medical field. Now a day's medical models are also fabricated with biocompatible materials which can be implant directly in to the patient. Bio-RP models are fabricated as per patient specific requirement. These models are not only having biocompatibility but also having high accuracy, low cost, time saving and biodegradable in specific scenarios. This article provides overall understanding of Bio-RP models, Bio-printing process, fabrication of RP methods and its applications.