Aim: The objective of the study is to detect predictive value of serum and urinary calcium and creatinine levels in the 3 rd trimester of normal pregnant and pre-eclamptic females. Materials And Methods: The present study was conducted in the Departments of Biochemistry and Obstetrics & Gynaecology, Government Medical College and hospital, Amritsar. The study included total 40 asymptomatic pregnant women at 20-28 weeks of gestation and aged between 21-35 years. In the present study, special biochemical investigations including serum calcium, urinary calcium, serum creatinine and urinary creatinine were carried out in the both groups (normal pregnant female and pre-eclamptic females both in their third trimester of pregnancy). Calcium clearance and creatinine clearances were also calculated. An effort was made to find out the correlation between these parameters on the basis of present findings and also with respect to the comparable and contrasting reports of other workers. Results: The mean serum calcium values in pre-eclamptic pregnant females were significantly lower (mean± S.E 8.3±0.19, t=3.3, p<0.01) as compare to normal pregnant females (mean± S.E 9.3± 0.233). Similar findings were observed in urinary calcium levels of pre-eclamptic pregnant females (mean±S.E 7.4±0.36, t=4.417, p<0.001) and in normal pregnant females in their 3 rd trimester of pregnancy (mean±S.E 9.8± 0.398). The mean serum creatinine values in pre-eclamptic pregnant females were significantly higher(mean± S.E 1.1± 0.041, t=8.70, p<0.001) as compared to the mean serum creatinine values in normal pregnant females in their 3 rd trimester of pregnancy(mean± S.E 0.64± 0.033).Similar findings were observed in urinary creatinine levels of pre-eclamptic pregnant females (mean±S.E 249.8±14.4,t=4.19,p<0.001) when compared to that of normal pregnant females in their 3 rd trimester of pregnancy (mean±S.E 179.6± 8.466). The mean calcium clearance value in pre-eclamptic pregnant females were significantly lower (mean± S.E 0.43±0.024, t=10.6, p<0.001) than mean calcium clearance values in normal pregnant females (mean± S.E 0.86± 0.033). The mean creatinine clearance value in pre-eclamptic pregnant females were significantly lower (mean± S.E 111.5 ± 7.06, t=5.8, p<0.001) than in normal pregnant females (mean± S.E 247± 21.96). The mean urinary calcium/urinary creatinine ratio in pre-eclamptic pregnant females were significantly lower (mean± S.E 0.03 ± 0.001, t=4.97, p<0.001) as compared to the calcium/urinary creatinine values in normal pregnant females (mean± S.E 0.05 ± 0.003). Conclusion: This study evaluates the serum calcium, urinary calcium, serum creatinine and urinary creatinine, Calcium clearance and creatinine clearances along with calcium/Creatinine Ratio which may be an effective parameter for detecting women at greater risk.
