synthesis, and biological evaluation of somw novel indolylpyrimidine derivatives

A novel series of required intermediate 5-((5-substituted3-phenyl-1H-indol-2-yl) methyleneamino)-6- amino-1,3-dimethylpyrimidine-2,4(1H,3H)-diones (3a-c) was prepared on condensation 5,6-diamino- 1,3-dimethylpyrimidine-2,4(1H,3H)-dione (1) with various 5- substituted 3-phenyl-1H-indole-2- carbaldehyde (2a-c) gave the respective Schiff bases, which on cyclization with thionly chloride afforded targeted compound 8-(5-substituted 3-phenyl-1H- indol-2-yl)-1,3-dimethyl-1H-purine- 2,6(3H,7H)-diones (4a-c). These newly synthesized compounds were screened for their antimicrobial and antioxidant activities, Compounds 3c, 4a and 4c exhibited promising antimicrobial activity. Compounds 3a, 3b, 4a and 4b showed potency of antioxidant activities.