Introduction: Boswelli dalzielii Hutch (Burseraceae) is a plant widely founded in the tropical region of Africa. The present study evaluated the in vivo antioxidant and enzymes of inflammation inhibitory profiles of n-Butanol fraction of stem bark from Boswelli dalzielii. Material and Methods: The in vivo antioxidant effects were evaluated using serum catalase, superoxide dismutase and thiobarbituric acid reactive substance assay methods. About enzyme of inflammation inhibitory activity, A5-LOX inhibitory, Hyaluronidase inhibitory and Xanthine oxidase inhibitory were determined. Results: Concerning the effects of n-Butanol fraction on the body weight of the treated rats. Fraction did not produce any significant (P>0.05)difference in body weight gain in treated rats when compared to the negative control. About the in vivo antioxidant effect of n-Butanol fraction on rats, it is noticed that the fraction produced a dose dependent decrease in the MDA levels in the serum. The serum MDA level of the group treated with 300 mg/kg of n-Butanol was significantly (p≤0.5) lower when compared to other treatment groups and the negative control group. Fraction also produced a dose dependent increase in the serum level of catalase activity. The serum catalase activity of the group treated with 300 mg/kg of n-Butanol was significantly (p≤0.5) higher whencompared to other treatment groups and the negative control group. Furthermore, fraction produceddose dependent increase in the serum level of superoxide dismutase activity. The serum superoxide dismutase activity of the groups treated with n-Butanol fraction were significantly (p≤0.5) higher when compared with the negative control group. Conclusions: These findings suggest that of stem bark from Boswelli dalzielii possess a potent antioxidant activity which may be responsible for some of its reported inflammatory activity and can be used as antioxidant supplement.
