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Banten Province in Indonesia is Leprosy Disease endemic territory. Dr. Sitanala Leprosy Hospital is one of hospital that treat leprosy cases from all over Indonesia. The purpose of this research is to know relations between contact history and BCG (Bacille Calmette-Guérin) vaccination status with leprosy case in Dr. Sitanala Leprosy Hospital. This research uses case-control study method. The research samples are 42 respondents as cases and 42 respondents as controls. The data analysis is conducted by univariate, bivariate using chi square test with degree of meaning 0,05 and calculate the value of Odd Ratio (OR), and also multivariate. From this research found that there is relation between contact history with leprosy patient (value of p=0,001<0,05; OR=4,5), and there is relation between BCG vaccination status (value of p=0,000<0,05; OR=47,5). The research summary is there is relation between contact history and BCG vaccination status with leprosy case in Dr. Sitanala Leprosy Hospital.