Synthesis of tetraazolo[1,5-a]quinolin analogues containing pyrimidine and thiazolidinone as antimicrobial agents
A series of new 2-(aryl)-3-(4-phenyl-6-[1,2,3,4]tetraazolo[1,5-a]quinolin-4-yl-2-pyrimidinyl)-1,3-thiazolan-4-one 15(a-j)has been synthesized by incorporating tetrazole, pyrimidine and thiazolidinone rings in one molecule for intensifying biological activity. Further, all the newly synthesized compounds have been assayed for their antimicrobial activity against Gram-positive bacteria viz. Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus, and Gram-negative bacteria viz.