Past Issue

Chronic myelogenous leukemia (CML) is a chronic myeloproliferative illness with an incidence of 1-2 cases per 100,000 people and an estimated 6,000 new patients diagnosed each year.This work identifies both known and new miRNAs in naïve hematopoietic stem cells and chronic myeloid leukemia (CML) stem cells using IonTorrent Next-Generation Sequencing (NGS) technology. Using miRNA profiling, significant differences in miRNA expression were found; certain miRNAs linked with epigenetic regulation and promoter methylation.

The Philadelphia (Ph) chromosome is produced by the reciprocal translocation of chromosomes 9 and 22, which is a hallmark of chronic myeloid leukaemia (CML), a clonal myeloproliferative illness. Organic cation transporter 1 (OCT-1) and organic cation/carnitine transporter 2 (OCTN2) are two membrane transporters that are necessary for the entry of imatinib into cells. Consequently, as their low expression lowers the intracellular imatinib concentration, membrane transporters have also been identified as significant factors to poor treatment response.

Background: Cryptosporidiosis due to Cryptosporidium parvum is an important zoonotic disease distributed world-wide and Cryptosporidium parvum was 1streported in 1907 in the gastric crypts of laboratory mouse by Edward Tyzzer. It is now well recognized in among immunocompromised individuals.In 1981 Michael Gottlieb and his colleagues at Los Angeles reported abroad range of opportunistic enteric parasites responsible for gastrointestinal infections like cryptosporidiosis, in patients with severe immunosuppression.

Fish are a vital component of human nutrition, providing high-quality protein, essential fatty acids, vitamins and minerals that contribute to health and food security. The present study aimed to perform a comparative nutritional characterization of three Indian major carpsLabeo rohita (rohu), Catla catla (catla) and Cirrhinus mrigala (mrigal) collected from wild and cultured sources in the Madurai district, Tamil Nadu. Proximate composition (protein, lipid, ash, moisture and carbohydrate) and amino acid profiles were analysed using standard AOAC and HPLC methods.

The development of nano-fertilizers, especially nano-urea, has created opportunities to improve agricultural nutrient use efficiency and possibly reduce environmental losses. Beyond its agronomic advantages, however, little is known about the ecological effects of nano-urea on soil biotic communities. The function of nano-urea as a modulator of soil biotic interactions is examined in this review, with an emphasis on how it affects cropping systems’ macrofaunal functionality and soil microbiota diversity.

Students in remote and rural villages worldwide confront a unique set of systemic challenges that severely impede their language acquisition and literacy development. A fundamental barrier is the imposition of instruction in a non-native language, often a national or official tongue, which creates a cognitive disconnect from a child’s first language. This situation is exacerbated by a critical shortage of teachers trained in effective multilingual pedagogy and a profound scarcity of reading materials in local languages, creating “print-poor” environments.

Background: Hypertension is a growing public health concern, even among young adults. Dietary nitrate supplementation, particularly from natural sources like beetroot juice, has shown potential in maintaining optimal blood pressure (BP) levels. This study assessed the effectiveness of beetroot juice in reducing systolic and diastolic blood pressure among normotensive nursing students.  Methods: A quasi-experimental one-group pre-test post-test design was employed among 50 normotensive nursing students aged 18–22 years from a selected nursing college in Tumkur.

Background: Type 2 Diabetes Mellitus (T2DM) is a significant public health challenge worldwide. Abelmoschus esculentus (okra) contains soluble fibers, polysaccharides, and antioxidants that may help regulate blood glucose. This study evaluated the effectiveness of okra water in improving glycaemic control and symptom burden among hospitalized T2DM patients. Methods: A quasi-experimental one-group pretest–posttest design was conducted among 95 hospitalized T2DM patients aged 25–70 years in Tumkur, India.

As a part of socio-economic survey organized by the State Climate Change Cell, Directorate of Environment and Climate Change, Government of Manipur,the team examines the biological diversity, water supplies, resource management policies, economics and demographics of Hoomivillage. The team interview local organization, government workers, local council, private business and farmers on the vulnerability and adaptation responses to climate change.

This mixed-methods study examines the proposition that teachers act first as moral educators and then as subject specialists, exploring how moral instruction relates to student moral development and academic outcomes in secondary science classrooms. Guided by objectives to describe teachers’ moral-education practices, assess relationships with student ethical reasoning and academic engagement, and explore teacher professional identity, the study sampled 18 science teachers and 384 students across seven public secondary schools in West Bengal.